| Game date | Opposing team | Score | r-h-e | / | r-h-e | Inns | Overall | SEC | Pitcher of record | Attend | Time | ||||
| Feb 13, 2010 | #9 MISSOURI-1 | 1-2 | L | 1-2-1 | / | 2-5-0 | 7 | 0-1-0 | 0-0-0 | Dunne (L 0-1) | 2243 | 2:00 | |||
| Feb 13, 2010 | #9 MISSOURI-2 | W | 9-0 | 9-9-0 | / | 0-3-3 | 5 | 1-1-0 | 0-0-0 | Morgan (W 1-0) | 2243 | 1:20 | |||
| Feb 14, 2010 | #9 MISSOURI | 0-9 | L | 0-2-2 | / | 9-9-0 | 5 | 1-2-0 | 0-0-0 | Dunne (L 1-1) | 2022 | 1:57 | |||
| Feb 16, 2010 | SOUTH ALABAMA | W | 6-3 | 6-8-1 | / | 3-6-2 | 7 | 2-2-0 | 0-0-0 | Sewell (W 1-0) | 1885 | 2:17 | |||
| Feb 19, 2010 | vs | Rhode Island | W | 17-3 | 17-17-4 | / | 3-5-4 | 5 | 3-2-0 | 0-0-0 | Locke (W 1-0) | 448 | 1:55 | ||
| Feb 19, 2010 | vs | #14 Ohio State | W | 5-3 | 5-6-2 | / | 3-7-0 | 7 | 4-2-0 | 0-0-0 | Dunne (W 1-2) | 617 | 2:15 | ||
| Feb 20, 2010 | vs | #14 Ohio State | W | 5-4 | 5-7-2 | / | 4-7-2 | 7 | 5-2-0 | 0-0-0 | Dunne (W 2-2) | 728 | 2:19 | ||
| Feb 20, 2010 | at | Stetson | W | 1-0 | 1-7-0 | / | 0-1-0 | 7 | 6-2-0 | 0-0-0 | Sewell (W 2-0) | 971 | 1:40 | ||
| Feb 21, 2010 | vs | #14 Ohio State | W | 7-1 | 7-9-1 | / | 1-6-3 | 7 | 7-2-0 | 0-0-0 | Dunne (W 3-2) | 339 | 2:17 | ||
| Feb 23, 2010 | at | UAB | W | 7-3 | 7-8-1 | / | 3-2-4 | 7 | 8-2-0 | 0-0-0 | Dunne (W) | 1323 | 2:30 | ||
| Feb 26, 2010 | vs | Maryland | W | 4-1 | 4-4-3 | / | 1-4-2 | 7 | 9-2-0 | 0-0-0 | Morgan (W 2-0) | 250 | 1:55 | ||
| Feb 26, 2010 | vs | Iowa | W | 5-4 | 5-6-1 | / | 4-8-4 | 7 | 10-2-0 | 0-0-0 | Dunne (W 5-2) | 250 | 2:20 | ||
| Feb 27, 2010 | vs | #4 Michigan | W | 10-6 | 10-12-4 | / | 6-9-2 | 7 | 11-2-0 | 0-0-0 | Sewell (W 3-0) | 500 | 2:30 | ||
| Feb 27, 2010 | vs | Nebraska | W | 11-3 | 11-10-2 | / | 3-5-0 | 6 | 12-2-0 | 0-0-0 | Locke (W 2-0) | 250 | 2:30 | ||
| Feb 28, 2010 | vs | UCF | 2-3 | L | 2-4-0 | / | 3-6-0 | 7 | 12-3-0 | 0-0-0 | Locke (L 2-1) | 200 | 1:50 | ||
| Mar 05, 2010 | #7 MICHIGAN | 2-5 | L | 2-5-0 | / | 5-8-1 | 7 | 12-4-0 | 0-0-0 | Dunne (L 5-3) | 2102 | 2:28 | |||
| Mar 06, 2010 | DEPAUL | W | 8-0 | 8-7-1 | / | 0-2-1 | 5 | 13-4-0 | 0-0-0 | Sewell (W 4-0) | 1990 | 1:52 | |||
| Mar 06, 2010 | #7 MICHIGAN | 2-4 | L | 2-4-0 | / | 4-11-0 | 7 | 13-5-0 | 0-0-0 | Morgan (L 2-1) | 2321 | 1:48 | |||
| Mar 07, 2010 | DEPAUL | W | 6-4 | 6-6-1 | / | 4-8-2 | 7 | 14-5-0 | 0-0-0 | Dunne (W 6-3) | 2022 | 2:11 | |||
| Mar 09, 2010 | LIBERTY | W | 10-7 | 10-6-0 | / | 7-9-2 | 7 | 15-5-0 | 0-0-0 | Locke (W 3-1) | 1854 | 3:15 | |||
| * | Mar 13, 2010 | at | #4 Georgia-1 | 0-3 | L | 0-1-2 | / | 3-5-1 | 7 | 15-6-0 | 0-1-0 | Dunne (L 6-4) | 1489 | 1:46 | |
| * | Mar 13, 2010 | at | #4 Georgia-2 | W | 8-5 | 8-7-1 | / | 5-7-0 | 7 | 16-6-0 | 1-1-0 | Sewell (W 5-0) | 1489 | 2:31 | |
| * | Mar 14, 2010 | at | #4 Georgia | W | 13-4 | 13-14-0 | / | 4-5-1 | 6 | 17-6-0 | 2-1-0 | Dunne (W 7-4) | 854 | 2:11 | |
| * | Mar 16, 2010 | at | Kentucky-1 | W | 7-2 | 7-8-1 | / | 2-5-0 | 7 | 18-6-0 | 3-1-0 | Dunne (W 8-4) | 201 | 2:35 | |
| * | Mar 16, 2010 | at | Kentucky-2 | 4-5 | L | 4-5-2 | / | 5-7-1 | 7 | 18-7-0 | 3-2-0 | Morgan (L 2-2) | 201 | 1:50 | |
| Mar 18, 2010 | FIU | W | 2-1 | 2-5-1 | / | 1-1-3 | 7 | 19-7-0 | 3-2-0 | Dunne (W 9-4) | 2008 | 1:46 | |||
| * | Mar 20, 2010 | SOUTH CAROLINA-1 | W | 8-0 | 8-11-0 | / | 0-3-1 | 5 | 20-7-0 | 4-2-0 | Dunne (W 10-4) | 2418 | 1:25 | ||
| * | Mar 20, 2010 | SOUTH CAROLINA-2 | W | 8-2 | 8-7-1 | / | 2-3-2 | 7 | 21-7-0 | 5-2-0 | Sewell (W 6-0) | 2418 | 2:15 | ||
| * | Mar 21, 2010 | SOUTH CAROLINA | W | 21-1 | 21-19-0 | / | 1-4-4 | 5 | 22-7-0 | 6-2-0 | Sewell (W 7-0) | 1911 | 1:55 | ||
| Mar 24, 2010 | UAB | W | 6-2 | 6-5-1 | / | 2-5-2 | 7 | 23-7-0 | 6-2-0 | Dunne (W 11-4) | 2060 | 2:00 | |||
| * | Mar 27, 2010 | #6 FLORIDA-1 | W | 10-4 | 10-8-1 | / | 4-3-2 | 7 | 24-7-0 | 7-2-0 | Dunne (W 12-4) | 2723 | 2:43 | ||
| * | Mar 27, 2010 | #6 FLORIDA-2 | 5-7 | L | 5-8-0 | / | 7-11-2 | (8) | 24-8-0 | 7-3-0 | Sewell (L 7-1) | 2948 | 2:49 | ||
| * | Mar 28, 2010 | #6 FLORIDA | 9-11 | L | 9-11-4 | / | 11-9-2 | 7 | 24-9-0 | 7-4-0 | Locke (L 3-2) | 2392 | 2:41 | ||
| * | Apr 02, 2010 | at | Auburn | W | 5-1 | 5-8-1 | / | 1-4-0 | 7 | 25-9-0 | 8-4-0 | Dunne (W 13-4) | 1633 | 2:26 | |
| * | Apr 03, 2010 | at | Auburn-1 | W | 9-1 | 9-5-0 | / | 1-4-3 | 7 | 26-9-0 | 9-4-0 | Morgan (W 3-2) | 1563 | 2:13 | |
| * | Apr 03, 2010 | at | Auburn-2 | W | 10-2 | 10-10-2 | / | 2-4-0 | 7 | 27-9-0 | 10-4-0 | Dunne (W 14-4) | 1562 | 2:48 | |
| * | Apr 07, 2010 | #14 LSU-1 | W | 3-1 | 3-6-1 | / | 1-1-0 | 7 | 28-9-0 | 11-4-0 | Dunne (W 15-4) | 2366 | 2:03 | ||
| * | Apr 07, 2010 | #14 LSU-2 | W | 4-3 | 4-5-0 | / | 3-3-1 | 7 | 29-9-0 | 12-4-0 | Dunne (W 16-4) | 2366 | 1:45 | ||
| Apr 10, 2010 | NORTHWESTERN | W | 12-1 | 12-12-0 | / | 1-3-2 | 5 | 30-9-0 | 12-4-0 | Dunne (W 17-4) | 2362 | 1:45 | |||
| Apr 11, 2010 | NORTHWESTERN | W | 11-1 | 11-10-1 | / | 1-2-1 | 5 | 31-9-0 | 12-4-0 | Dunne (W 18-4) | 2191 | 1:40 | |||
| Apr 13, 2010 | at | Mississippi Valley | W | 6-1 | 6-7-0 | / | 1-2-3 | 7 | 32-9-0 | 12-4-0 | Sewell (W 8-1) | 300 | 1:50 | ||
| * | Apr 17, 2010 | MISSISSIPPI-1 | W | 14-0 | 14-7-0 | / | 0-1-0 | 5 | 33-9-0 | 13-4-0 | Dunne (W 19-4) | 2806 | 1:59 | ||
| * | Apr 17, 2010 | MISSISSIPPI-2 | W | 8-3 | 8-12-0 | / | 3-7-1 | 7 | 34-9-0 | 14-4-0 | Morgan (W 4-2) | 2806 | 2:31 | ||
| * | Apr 18, 2010 | MISSISSIPPI | W | 3-1 | 3-2-0 | / | 1-2-1 | 7 | 35-9-0 | 15-4-0 | Dunne (W 20-4) | 2482 | 2:26 | ||
| Apr 20, 2010 | TROY | W | 12-2 | 12-9-2 | / | 2-3-0 | 5 | 36-9-0 | 15-4-0 | Locke (W 4-2) | 2118 | 1:29 | |||
| * | Apr 24, 2010 | at | Arkansas-1 | W | 6-1 | 6-8-3 | / | 1-6-1 | 7 | 37-9-0 | 16-4-0 | Morgan (W 5-2) | 910 | 1:56 | |
| * | Apr 24, 2010 | at | Arkansas-2 | W | 16-8 | 16-15-2 | / | 8-9-4 | 6 | 38-9-0 | 17-4-0 | Locke (W 5-2) | 910 | 2:12 | |
| * | Apr 25, 2010 | at | Arkansas | W | 8-6 | 8-9-2 | / | 6-8-0 | 7 | 39-9-0 | 18-4-0 | Sewell (W 9-1) | 719 | 2:21 | |
| Apr 28, 2010 | #7 GEORGIA TECH | W | 13-1 | 13-12-0 | / | 1-2-1 | 5 | 40-9-0 | 18-4-0 | Dunne (W 21-4) | 2045 | 2:04 | |||
| * | May 01, 2010 | #16 TENNESSEE-1 | W | 4-2 | 4-6-2 | / | 2-7-0 | 7 | 41-9-0 | 19-4-0 | Dunne (W 22-4) | 2542 | 2:21 | ||
| * | May 01, 2010 | #16 TENNESSEE-2 | W | 7-6 | 7-7-2 | / | 6-9-2 | 7 | 42-9-0 | 20-4-0 | Morgan (W 6-2) | 2848 | 2:37 | ||
| * | May 08, 2010 | at | Mississippi State-1 | W | 10-1 | 10-11-1 | / | 1-4-2 | 6 | 43-9-0 | 21-4-0 | Dunne (W 23-4) | 976 | 1:50 | |
| * | May 08, 2010 | at | Mississippi State-2 | W | 8-2 | 8-7-2 | / | 2-6-2 | 7 | 44-9-0 | 22-4-0 | Morgan (W 7-2) | 976 | 1:59 | |
| * | May 09, 2010 | at | Mississippi State | W | 6-1 | 6-5-1 | / | 1-5-1 | 7 | 45-9-0 | 23-4-0 | Dunne (W 24-4) | 683 | 1:50 | |
| May 13, 2010 | at | Arkansas | W | 9-0 | 9-8-0 | / | 0-2-1 | 5 | 46-9-0 | 23-4-0 | Dunne (W 25-4) | 1125 | 2:00 | ||
| May 14, 2010 | vs | #15 Tennessee | W | 4-3 | 4-10-1 | / | 3-3-0 | 7 | 47-9-0 | 23-4-0 | Dunne (W 26-4) | 906 | 2:20 | ||
| May 15, 2010 | vs | #11 LSU | W | 5-4 | 5-8-1 | / | 4-5-0 | 7 | 48-9-0 | 23-4-0 | Dunne (W 27-4) | 1510 | 2:40 | ||
| May 21, 2010 | ALCORN STATE | W | 9-0 | 9-9-0 | / | 0-2-1 | 5 | 49-9-0 | 23-4-0 | Sewell (W 10-1) | 2323 | 1:14 | |||
| May 22, 2010 | LIPSCOMB | W | 5-2 | 5-4-1 | / | 2-5-2 | 7 | 50-9-0 | 23-4-0 | Dunne (W 28-4) | 2439 | 1:59 | |||
| May 23, 2010 | LIPSCOMB | W | 6-0 | 6-6-0 | / | 0-2-2 | 7 | 51-9-0 | 23-4-0 | Dunne (W 29-4) | 2170 | 2:01 | |||
| May 29, 2010 | #19 HAWAI'I | W | 8-0 | 8-9-0 | / | 0-2-3 | 5 | 52-9-0 | 23-4-0 | Dunne (W 30-4) | 2918 | 1:42 | |||
| May 29, 2010 | #19 HAWAI'I | 7-8 | L | 7-12-1 | / | 8-9-1 | 7 | 52-10-0 | 23-4-0 | Dunne (L 30-5) | 3218 | 2:30 | |||
| May 30, 2010 | #19 HAWAI'I | 4-5 | L | 4-6-0 | / | 5-5-0 | 7 | 52-11-0 | 23-4-0 | Dunne (L 30-6) | 3130 | 2:09 |
|
* = Conference game
() extra inning game |